Sub-millimeter PET Technology
Currently, the spatial resolution of most dedicated small animal PET Scanners is only 1-2 mm, which is inadequate for molecular imaging of laboratory mouse, the most frequently used animal model. For instance, the size of a mouse brain is approximately 1.5 cm and the diameter of a mouse abdominal aorta is approximately 1 mm, requiring a spatial resolution of ~ 0.5 mm to obtain comparable imaging results to that of a human using a 5 mm PETscanner.*
With its proprietary sub-millimeter detector fabrication and image processing technologies, MadicLab has launched its small animal PET systems with a spatial resolution of 0.42 mm. The three- dimensional spatial resolution of this ultra-high resolution PET is 4.6-17 times higher than that of conventional PET systems on the market, allowing it to display the minute details of tiny mouse organs never before seen.
*Yongfeng Yang, Julien Bec, et al. J Nucl Med. 2016 July ; 57(7): 1130–1135.
Ultra-high sensitivity technolog
Positron Emission Tomography (PET) plays an incomparable role in detecting the metabolic function of living animals, because it has extremely high sensitivity compared with other imaging. Almost cellular level’s perception, it have played an important role not only in oncology, neuroscience, cardiology, genetics, radiology, immunology, genomics and many other disciplines, but also in new drug’s research and development. Especially in primate animals’ experimental, compared with small animal ( mainly mice), it has its irreplaceable role Whether in drug screening on early stage and pharmacological efficacy test or drug safety evaluation in middle stage based on its genetic relationship to human beings. However, traditional PET uses ring detectors (Axial FOV: 9~50cm), the sensitivity is low and uneven, and the imaging time is 1~30 minutes, which seriously limits its scanning speed. It can only trace the dynamic imaging in part, such as brain and heart, which cannot meet the requirement to do the study of the large animals’ pharmacokinetics for whole-body dynamic imaging.
Shandong Madic Technology Co., Ltd. was the first one in the world to propose "ultra-high sensitivity PET technology", and upgraded the traditional ring detector to 4π three-dimensional angle detector. The PET scanning time was increased from minutes to sub-seconds, Ultra-high sensitivity PET will bring new imaging tools to the research and development of biomedical fields such as pharmacology, pathology, and physiology, and it has an invaluable effect on biomedicine as well.