Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion

2021-07-09 14:39

《Lung tumor》

Title：《Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion》（译：《非编码 RNAs 通过 ceRNA 介导的 miRNA 逃避参与 CLDN4 的调控网络》）
Abstract：Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.（译：成千上万的基因在癌症中扮演着重要的角色进展。由于基因的功能不是孤立的，所以它们可以被分组成基于“网络”的他们的互动。在本研究中，我们发现了一个调节胃粘膜Claudin-4的网络巨蟹座我们观察到Claudin-4在胃癌中上调，并与胃癌的发生有关预后差。Claudin-4增强AGS、HGC-27的增殖、侵袭和EMT， SGC-7901细胞，miR-596和miR-3620-3p可逆转。此外， lncRNA-KRTAP5-AS1和lncRNA-TUBB2A可作为竞争性内源性rna来表达影响Claudin-4的功能。我们的结果表明非编码rna起重要作用在Claudin-4调控网络中的作用。因此，非编码rna应该被考虑作为胃癌的潜在生物标志物和治疗靶点。）
Periodical：Journal of cellular physiology
Impact Factor: 12.353
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Researcher：Junhua Zhao
Research unit：Department of oncology, First Affiliated Hospital of China Medical University
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