Anti-PADI4 antibody suppresses breast cancer by repressing the citrullinated fibronectin in the tumo
2022-06-29文献信息（原文下载：抗 PADI4 抗体通过抑制肿瘤微环境中的瓜氨酸纤连蛋白来抑制乳腺癌）近日，青岛大学附属医院医学研究中心常晓天教授团队的研究成果"Anti-PADI4 antibody suppresses breast cancer by repressing the citrullinated fibronectin in the tumor microenvironment(抗 P...
十二指肠空肠搭桥术后近端肠葡萄糖转运与代谢在II型糖尿病大鼠血糖控制中的作用
2022-02-08原文链接：https://doi.org/10.1007/s11695-021-05871-3背景尽管胃部手术可以显著改善II型糖尿病（T2DM）的血糖稳态，但其机制尚不清楚。本研究评估了十二指肠空肠旁路（DJB）手术后肠道葡萄糖传感、葡萄糖转运和代谢在T2DM大鼠消化肢（A肢）中的作用。方法采用高糖高脂饮食和低剂量链脲佐菌素注射诱导T2DM大鼠模型。将糖尿病大鼠分为两组：DJB手术组（T2...
Central GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jej
2021-09-28减肥手术后认知功能的改善已被强调，但其潜在机制仍然难以捉摸。在肥胖和糖尿病大鼠上进行Roux-en-Y胃分流术（RYGB）、十二指肠空肠分流术（DJB）和假手术（sham），并在侧脑室（ICV）内注射胰高血糖素样肽-1（GLP-1）analog liraglutide（Lira）、antagonist exendin-（9–...
基于NEMA NU 4-2008标准的小动物PET/CT系统性能评估
2021-09-13论文信息题目：《Technical Note Performance evaluation of a small-animal PETCT system based on NEMA NU 4– 2008 standards》期刊：MedicalPhysics作者：刘琼研究单位：徐州医科大学1.论文摘要目的:MetisTM PET/CT是一种自主研发的、基于硅光电倍增管(SiPM)探测器的啮齿...
Proprotein Convertase Subtilisin/ Kexin Type 9 Promotes Gastric Cancer Metastasis and Suppresses Apo
2021-07-09Objective: To examine the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) on gastric cancer (GC) progression and prognosis, and to explore the underlying mechanism. Methods PCSK9 expre
Duodenal-Jejunal Bypass Ameliorates Type 2 Diabetes Mellitus by Activating Insulin Signaling and Imp
2021-07-09Duodenal-jejunal bypass (DJB) can dramatically improve type 2 diabetes independent of weight loss and food restriction. Increasing evidence has demonstrated that brain insulin signaling plays an impor
The orphan nuclear receptor RORα is a potential endogenous protector in renal ischemia/ reperfusion
2021-07-09 In summary, our study provides experimental evidence showing that RORα is a novel endogenous protector against renal I/R injury and that ROR-α activation is a promising therapeutic strategy for the p
Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced he
2021-07-09《心脏衰竭》题目：《Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced heart failure through autophagy enhancement》（译：《线粒体钙单向递质抑制通过自噬增强对压力超负荷引起的心力衰竭提供心脏保护作用》）Ab...
Bioengineered H- Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosi
2021-07-09《动脉粥样硬化》题目：《Bioengineered H- Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis》（译：《生物工程化的H-铁蛋白纳米笼用于动脉粥样硬化中易损斑块的定量成像》）Abstract：Inflammation and calcification conco...
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
2021-07-09《肺部肿瘤》题目：《Non-coding RNAs participate in the regulatory network of
CLDN4 via ceRNA mediated miRNA evasion》（译：《非编码 RNAs
通过 ceRNA 介导的 miRNA 逃避参与 CLDN4 的调控网络》）Abstract：Thousands of genes have been wel...
Evaluation of Novel 64Cu-Labeled Theranostic Gadolinium-Based Nanoprobes in HepG2 Tumor-Bearing Nud
2021-07-09Radiation therapy of liver cancer is limited by low tolerance of the liver to radiation. Radiosensitizers can effectively reduce the required radiation dose. AGuIX nanoparticles are small, multifuncti
LINC00852 Promotes Lung Adenocarcinoma Spinal Metastasis by Targeting S100A9
2021-05-20LINC00852 Promotes Lung Adenocarcinoma Spinal Metastasis by Targeting S100A9
CX3CL1/fractalkine enhances prostate cancer spinal metastasis by activating the Src/FAK pathway
2021-05-20在本研究中，观察到CX3CL1/C-X3-C基序趋化因子受体1（CX3CR1）在有脊柱转移的前列腺癌组织中较原发肿瘤高表达。
Long noncoding RNA H19 participates in metformin-mediated inhibition of gastric cancer cell invasion
2021-05-20Many studies have also shown that long noncoding RNAs (lncRNAs) play important roles in many biological processes. Therefore, we aimed to explore whether lncRNAs participate in the mechanisms by which